Explains the effect of the COVID-19 pandemic on clinical research and provides suggestions for which studies should proceed, which should pivot to research on the pandemic, which should be paused, and which should stop.
Summarizes clinical trial evidence suggesting a possible link between angiotensin receptor blocker use and cancer, additional clinical evidence tending to refute a link, basic science evidence, and recent information about the problem of potentially cancer-causing impurities found in some angiotensin receptor blocker products.
Invited editorial comment on a new approach to evaluating whether patients are similar to those actually enrolled in a clinical trial, as opposed to the inclusion and exclusion criteria.