**Context:** Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary aldosteronism (PA). Particularly, mineralocorticoid receptor antagonists (MRA) might raise renin …
Analysis of the relationship between gene expression in the human renal cortex and urinary extracellular vesicles, as well as a study of intentional modulation of the renin-angiotensin-aldosterone system in humans with attention to corresponding changes in mRNA transcript abundance in the urine supernatant.
A pragmatic discussion of the diagnosis and treatment of primary aldosteronism.
Our and others' research presented at the 2018 International Society for Extracellular Vesicles' Biomarkers Workshop, Birmingham, UK.
**OBJECTIVE:** Correct subtyping of primary aldosteronism (PA) is essential for good surgical outcomes. Adrenal vein sampling (AVS) and/or computed tomography (CT) are used for PA subclassification. Clinical and/or biochemical improvement after …
**BACKGROUND:** A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. **METHODS:** The Dallas Heart Study is a large, multiethnic …
Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension. Mineralocorticoids have been hypothesized to have a pathogenic role in human obesity-associated hypertension. In this …